Search results for " drug-induced liver injury"

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Clinical features and outcomes of patients with drug-induced autoimmune hepatitis: a retrospective cohort study.

2014

Abstract Background Drugs and herbal products can induce autoimmune hepatitis. We assessed frequency and clinical outcomes of patients suffering from drug-induced autoimmune hepatitis. Methods All patients with drug-induced liver injury admitted between 2000 and 2011 were retrospectively studied. Diagnoses of drug-induced autoimmune hepatitis and idiopathic autoimmune hepatitis were made according to simplified criteria. After discharge, all patients had regular follow-up and were contacted to update outcomes. Results Among 10,270 in-hospital patients, 136 (1.3%) were diagnosed with drug-induced liver injury. Among them, 12 (8.8%) were diagnosed as drug-induced autoimmune hepatitis (41.7% m…

AdultMalemedicine.medical_specialtyDrug-induced liver injuryAdolescentAutoimmunityAutoimmune hepatitisSettore MED/08 - Anatomia Patologicamedicine.disease_causeGastroenterologyAutoimmunityYoung AdultInternal medicinemedicineHumansAutoimmunity; Drug-induced liver injury; Human leucocyte antigens; Liver biopsy --------------------------------------------------------------------------------Liver biopsy --------------------------------------------------------------------------------AgedRetrospective StudiesSettore MED/04 - Patologia GeneraleLiver injurySettore MED/12 - GastroenterologiaHepatologymedicine.diagnostic_testbusiness.industryGastroenterologyGamma globulinRetrospective cohort studyHuman leucocyte antigenJaundiceMiddle Agedmedicine.diseaseHepatitis AutoimmuneTreatment OutcomeLiver biopsyCohortImmunologyFemalemedicine.symptomChemical and Drug Induced Liver InjurybusinessImmunosuppressive AgentsFollow-Up StudiesDigestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
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A phenobarbital overdose: a case report

2017

Background: Phenobarbital is a long-acting barbiturate, responsible for many cases of poisoning, from unintentional overdose or attempted suicide. We report a case of phenobarbital overdose in a patient with history of depression. Patients and Methods: A 60 year old woman was admitted to our Internal Medicine Unit for drowsiness, irritability, difficulties in the maintenance of an upright position, dysphasia and weakness. She was suffering from depression and epilepsy and treated with phenobarbital 150 mg/die. Results: At the admittance, she had high fever and neck stiffness; phenobarbital serum levels were 71.2 mcg/ml (3 times u.n.l.); aminotransferases were 12-17u.n.l. Arterial blood pres…

Phenobarbital DILI drug-induced liver injurySettore MED/09 - Medicina Interna
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The use of same in chemotherapy-induced liver injury

2018

Drug-induced liver injury (DILI) remains the most common cause of acute liver failure in the Western world. Chemotherapy is one of the major class of drugs most frequently associated with idiosyncratic DILI. For this reason, patients who receive chemotherapy require careful assessment of liver function prior to treatment to determine which drugs may not be appropriate and which drug doses should be modified. S-adenosylmethionine (SAMe) is an endogenous agent derived from methionine. Its supplementation is effective in the treatment of liver disease, in particular intrahepatic cholestasis (IHC). The target of this review is to analyze the mechanisms of hepatotoxicity of the principal antican…

medicine.medical_specialtyDrug-Related Side Effects and Adverse ReactionsDrug-induced liver injurySettore MED/06 - Oncologia Medicamedicine.medical_treatmentAntineoplastic AgentsGastroenterology03 medical and health sciencesLiver disease0302 clinical medicineCholestasisChemotherapy inducedInternal medicineNeoplasmsmedicineAnimalsHumansChemotherapyLiver injuryChemotherapyS-adenosylmethioninebusiness.industryHepatotoxicityHematologymedicine.diseaseOncologyCholestasi030220 oncology & carcinogenesisImmunohistochemistry030211 gastroenterology & hepatologyChemotherapy; Cholestasis; Drug-induced liver injury; Hepatotoxicity; S-adenosylmethionine; Hematology; OncologyLiver functionChemical and Drug Induced Liver InjuryComplicationbusiness
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